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The NIMH Collaborative HIV/STD Prevention Trial was a collective effort between six countries to determine the efficacy of a community-based HIV prevention intervention. This intervention sought to identify representatives in the community called as community popular opinion leaders (CPOLs) who would in turn, spread the prevention message among their social group.
   
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The key and novel approach in this intervention was in identifying social networks or naturally occurring social groups in the community. Then, appropriate representatives from these networks were recruited as CPOLs and trained to conduct prevention education. The intervention was implemented in slum communities in Chennai. As this was a diverse community, the trial was conducted first as ethnographic studies to identify networks in the community. These studies helped finding appropriate methods of identifying and recruiting CPOLs. The studies also helped to understand cultural practices and beliefs related to HIV prevention and transmission.

With this knowledge and input from the community the intervention were designed. This intervention was expected to strengthen norms about safer sexual behavior and encourage risk reduction in the communities. Assessments were conducted by surveys and collection of biological specimens at baseline and at the end of the project were made. The efficacy of the intervention were determined by examining change in risk behaviors and HIV/STD incidence in Chennai and other countries. The intervention was for five years in duration from 2000 to 2005.
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