
Prof
David D Celentano, Deputy Chair, Department of Epidemiology,
Johns Hopkins Bloomberg School of Public Health, USA,
inaugurated the m2000rt RealTime PCR system (ABBOTT
Diagnostics, Germany) at the YR Gaitonde Center for
AIDS Research and Education (YRGCARE) in the VHS Campus
on IT Corridor in Adyar on June 22nd 2007. The equipment
was generously donated by ABBOTT Diagnostics, Germany.
The RealTime PCR has been recently approved by the
US Food and Drug Administration, USA to measure the
HIV viral load. The RealTime PCR is modification of
the standard PCR and provides greater accuracy in
measuring the quantity of HIV RNA circulating in the
patient's blood (viral load). This test is sensitive
at detecting low HIV viral loads and is also faster
in providing results. This test will be validated
appropriately for the Indian setting and should be
available to the public by the end of July. The viral
load is the gold standard in measuring the efficacy
of HIV treatment and is routinely used in most countries
in the European Union as well as USA. A high viral
load among patients on HAART is also the first sign
of treatment failure. However, it is seldom used in
the Indian setting due to its prohibitive cost (Rs.
4000). The RealTime PCR, once validated, will be available
to the public at less than Rs. 1000. This will in
turn increase its utilization in clinical practice
resulting in the identification of treatment failure
at the earliest stage, thereby minimizing the development
of drug resistance.