Research

YRG CARE started out primarily as an organization to promote HIV awareness, and foster education about HIV, sexuality and related issues. As YRG CARE expanded, an outpatient clinic was added, followed by an inpatient ward. This in turn necessitated laboratory services. An essential component of holistic treatment was counseling. Associated elements included behavioral change, and a focus on high-risk marginalized communities such as commercial sex workers, intravenous drug users, and men who have sex with men and the LGBT community. So over the course of years, YRG CARE’s research activities have expanded to include all of these areas, as well as epidemiology and prevention. Our research in these areas is presented under the various sub-section in this section: clinical, basic sciences/laboratory, and epidemiology/prevention. There is also a sub-section on research governance, with details of our Institutional Review Board (IRB) which oversees the bio-ethical aspects of our research, and the Community Advisory Board (CAB) which helps us interact with the communities we serve.

Overview of Clinical Research

Over 300 papers and other publications covering YRG CARE’s clinical research have been published in peer reviewed medical journals, books and guidelines. These publications cover:

  1. The clinical spectrum and natural history of HIV disease in Southern India.
  2. The safety, tolerability, efficacy and effectiveness of generic antiretroviral drugs in Indian patients.
  3. The impact of antiretroviral therapy on opportunistic infections (OIs) and mortality.
  4. The short term and long adverse effects of antiretroviral therapy (ARV) in Indian patients and the pattern of genotypic mutations among patients failing 1st line highly active antiretroviral therapy (HAART).
  5. Randomized clinical trials that address the issue of when to start HAART and with which drugs and when to switch to other drugs safety and efficacy of newer ARV usage in prevention.
  6. The cost effectiveness of various interventions.

Contribution to Book Chapters and Treatment Guidelines:

  1. HIV Disease in India-Handbook for Dental Professionals. SR Prabhu Anil Kohli Bhasker Rao, a publication of the Dental Council of India, First Indian Edition 2007.
  2. Management of the HIV-infected patient. Editors: S. Crowe, J. Hoy and J. Mills, 2nd Edition. London: Martin Dunitz, 2002. Isbn 1-901865-28-2
  3. Ocular lesions in AIDS in India: A report of first two cases in India. Jyotimay Biswas, HN Madhavan, SS Badrinath, 1995, Vol. 43, Issue 2, Page : 69-72; Sankara Nethralaya, Medical Research Foundation, Madras, India.
  4. Scaling up antiretroviral therapy in resource-limited settings : treatment guidelines for a public health approach. World Health Organisation(WHO-Geneva), Dept. of HIV/AIDS, 2004. Edition: 2003 rev. ISBN: 9241591552 (English) Treat 3 Million by 2005 Initiative World Health Organization. Dept. /AIDS
  5. HIV Diagnosis and Monitoring of Antiretroviral Therapy. World Health Organisation(WHO), July 2004.
  6. The AIDS Pandemic, 1st Edition Impact on Science and Society. Editor(s) :Mayer & Pizer, Feb 2005; Imprint: Academic Press; eBook ISBN:9780080475806; Print Book ISBN :9780124652712
  7. The HIV Pandemic: Local and Global Implications. Eduard J. Beck, Nicholas Mays, Alan W. Whiteside, and José M. Zuniga, 2007. Published to Oxford Scholarship Online: September 2009
    Print ISBN-13: 9780199237401
  8. Guidelines on Antiretroviral Therapy for HIV infection in Adults and Adolescents in Resource Limited Settings- Towards Universal Access. World Health Organisation(WHO), 2006.
  9. Guidelines on Co-trimoxazole prophylaxis for HIV-related infections among Children, Adolescents and Adults in Resource Limited Settings. World Health Organisation(WHO), 2006.
  10. Management of HIV Infection and Antiretroviral Therapy in Adults and Adolescents: A Clinical Manual, World Health Organisation (WHO), Regional Office for South-East Asia, 2007; ISBN:978920222897
  11. Treatment Guidelines on Antiretroviral Therapy for HIV infection in Adults and Adolescents in Resource Limited Settings- Towards Universal Access, World Health Organisation(WHO), 2010.
  12. Rapid advice: Diagnosis, prevention and management of cryptococcal disease in HIV-infected adults, adolescents and children. World Health Organisation, December2011. ISBN: 978 92 4 150297 9
  13. Consolidated Treatment Guidelines on the use of Antiretroviral Drugs for treating and preventing HIV infection. World Health Organisation (WHO), June 2013
  14. The use of lateral flow urine lipoarabinomannan assay (LF-LAM) for the diagnosis and screening of active tuberculosis in people living with HIV. Policy update, World Health Organisation (WHO), 2015. ISBN: 978 92 4 150963 3. WHO reference number: WHO/HTM/TB/2015.25
  15. Consolidated Treatment Guidelines on the use of Antiretroviral Drugs for Treating and Preventing HIV infection. World Health Organisation (WHO), December 2015