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Study On The Hepatitis B Virus Vaccine Response Among HIV-1 Infected Individuals - A Multicentre Study

Principal Investigators
Dr. H. Syed Iqbal, Dr. A. Pradeep
Funding Agency
ICMR, Government of India
Dr. Sarvode. N. Mothi, Dr. V.H.T. Swamy, Dr. Srirama (Asha Kirana Hospital), Dr. Rajesh Sengodan, Dr. Thirunavukkarasu Dharmalingam, Dr. L. Arunachalam (Government Mohan Kumaramangalam Medical College and Hospital, Shevapet, Salem, Tamil Nadu)


To study Hepatitis B Virus (HBV) vaccine response among HIV-1 infected children and adults; To study HBV vaccine response versus clinical and/or immunological (CD4+ T-cell counts) factors; To study other underlying factors that are associated with non-responders.


Hepatitis B Virus (HBV) infection causes chronic liver diseases and slowly progresses to cirrhosis and hepatocellular carcinoma (HCC) during the course of infection. The Hepatitis B vaccine was proved to be effective in preventing HBV transmission by achieving protective immune response in the host, however, studies have witnessed suboptimal response especially in HIV infected individuals. This study is designed to find out the possible causes associated with suboptimal immune response and Single Nucleotide Polymorphism (SNP) gene polymorphism among HBV vaccine non-responding HIV infected individuals. Understanding the role of genetic background will be helpful to study the immune processing of antigen presenting cells, needed for eliciting the effective immune response to HBV vaccination.